Environmental Toxicology 27(5)
Overview of new articles on POPs in a new issue of the Environmental Toxicology journal
Subchronic effects of perfluorooctanesulfonate exposure on inflammation in adult male C57BL/6 mice
pages 285–296
Guang-Hui Dong, Ying-Hua Zhang, Li Zheng, Zai-Fu Liang, Yi-He Jin and Qin-Cheng He
- Previous studies indicate that exposure to perfluorooctanesulfonate (PFOS), a ubiquitous and highly persistent environmental contaminant, induces immunotoxicity in mice. However, few studies have specifically assessed the effects of PFOS on inflammation. This study utilized a standard 60-day oral exposure period to assess the effects of PFOS on the response of inflammatory cytokines [tumor necrosis factor α (TNF-α), interleukin-1 β (IL-1β), and interleukin-6 (IL-6)].
pages 316–320
Wei Wei, Xiao-Feng Li, Xiao-Nuan Li, Xue-Min Chen, Ai-Lin Liu and Wen-Qing Lu
- Benzo(a)pyrene (BaP) never exists in the environment as a single compound but always coexists with other chemicals. These chemicals may affect the toxicity of BaP. Our previous study confirmed that polychlorinated biphenyls (PCBs), which were recently found coexisting with BaP in various environmental media, dramatically enhanced the genotoxicity of BaP. But the known mechanisms associated with this phenomenon are limited. Because BaP's genotoxicity is highly associated with its ability to induce the oxidative stress, we propose that the coexistence of PCBs may enhance BaP's genotoxicity by affecting BaP-induced oxidative stress. In this study, the HepG2 cells were treated with either BaP (50 μM), 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) (0.01, 0.1, 1, and 10 nM), or pretreated with PCB126 followed by a coexposure to BaP and PCB126.
16.4.2012
