Environmental Research 116

Factors influencing combined exposure to three indicator polychlorinated biphenyls in an adult cohort from Bolivia

Pages 17-25
J.P. Arrebola, E. Mutch, M. Cuellar, M. Quevedo, E. Claure, L.M. Mejía, M. Fernández-Rodríguez, C. Freire, N. Olea, L.A. Mercado

• Multivariate models were used to predict serum and adipose tissue PCB concentrations.
• Fatty food consumption was related to both serum and adipose tissue concentrations.
• Serum concentrations were also predicted by occupation.
• Predictors of adipose tissue concentrations also included age, smoking and residence.
• BMI was an important modifier of the associations found.

Pre-industrial accumulation of anthropogenic polycyclic aromatic hydrocarbons found in a blanket bog of the Iberian Peninsula

Pages 36-43
Xabier Pontevedra-Pombal, Ledicia Rey-Salgueiro, Mercedes S. García-Falcón, Elena Martínez-Carballo, Jesús Simal-Gándara, Antonio Martínez-Cortizas

• The deposition of anthropogenic PAHs began earlier than industrial revolution.
• PAHs composition and other environmental proxies marked changes in sources.
• Anthropogenic fires cause accumulation of PAHs in the Middle Ages from local sources.
• Regional anthropogenic sources of PAHs increased from industrialisation.

Adverse effects in risk assessment: Modeling polychlorinated biphenyls and thyroid hormone disruption outcomes in animals and humans

Pages 74-84
Fred Parham, Amber Wise, Daniel A. Axelrad, Kathryn Z. Guyton, Christopher Portier, Lauren Zeise, R. Thomas Zoeller, Tracey J. Woodruff

• We model the relationship between PCBs and thyroid hormones in animals and humans.
• We compare dose–response for PBS and thyroid hormones between animals and humans.
• In animals, increasing PCBs are associated with decreasing thyroid hormones.
• In humans, increasing PCBs are generally associated with decreasing thyroid hormones.
• Estimated animal dose–response for PCB/thyroid underpredicts that in humans.

Perfluorooctanoic acid (PFOA), an emerging drinking water contaminant: A critical review of recent literature

Pages 93-117
Gloria B. Post, Perry D. Cohn, Keith R. Cooper

• PFOA persists in the environment and has a long half-life in human serum.
• Drinking water can be an important source of human exposure to PFOA.
• Drinking water exposure to PFOA increases serum levels more in infants than adults.
• Low PFOA exposure is associated with many endpoints in humans; causality not proven.
• Mouse developmental effects occur at PFOA serum levels seen in some exposed humans.

1.6.2012

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